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Title: A Review of Medical Errors in Laboratory Diagnostics and Where We Are Today.
Creator: Zemplinski, Julie
Abstract / Description: While many areas of health care are still struggling with the issue of patient safety, laboratory diagnostics has always been a forerunner in pursuing this issue. Significant progress has been made since the release of “To Err is Human.”1 This article briefly reviews laboratory quality assessment and looks at recent statistics concerning laboratory errors.
Date Issued: 2012-02-01
Identifier: fgcu_ir_000734
Format: Citation

Title: Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates.
Creator: Gupta, Jayanta, Stevenson, Michelle D., Sellins, Stacey, Grube, Emilie, Schroer, Kathy, Wang, Ning, Khurana Hershey, Gurjit K.
Abstract / Description: Allergic sensitization is very prevalent and often precedes the development of allergic disease. This study examined the association of race with allergic sensitization among healthy children with no family history of atopy.
Date Issued: 2007-08-01
Identifier: fgcu_ir_000727
Format: Citation

Title: Airborne microorganisms, endotoxin, and (1->3)-β-Dglucan exposure in greenhouses and assessment of respiratory symptoms among workers.
Creator: Gupta, Jayanta, Adhikari, Atin, Wilkins, III, John R., Olds, Rolanda L., Indugula, Reshmi, Cho, Kyungmin J., Li, Chunlei, Yermakov, Michael
Abstract / Description: Greenhouse operations are an important sector of the horticulture industry, also known as the Green Industry. The objectives of this study were (i) to investigate exposure levels to airborne culturable fungi, bacteria (total culturable bacteria and actinomycetes), endotoxin, and (1→3)-β-D-glucan in three Midwest greenhouses during summer and winter using multiple exposure assessment methods; (ii) characterize the load of microorganisms on greenhouse floors and determine potential microbial...
Show moreGreenhouse operations are an important sector of the horticulture industry, also known as the Green Industry. The objectives of this study were (i) to investigate exposure levels to airborne culturable fungi, bacteria (total culturable bacteria and actinomycetes), endotoxin, and (1→3)-β-D-glucan in three Midwest greenhouses during summer and winter using multiple exposure assessment methods; (ii) characterize the load of microorganisms on greenhouse floors and determine potential microbial source strengths of the floors for aerosolizing microbial biocontaminants, and (iii) to estimate the prevalence of rhinitis, wheezing, asthma, and other respiratory symptoms/conditions among greenhouse workers.
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Date Issued: 2010-12-20
Identifier: fgcu_ir_000726
Format: Citation

Title: Assessment of Oral Health Knowledge, Attitude, Utilization and Barriers toward Professional Dental Care among Adults in Central Rural India.
Creator: Kahar, Payal, Shevon Harvey, Idethia, Tisone, Christine A., Khanna, Deepesh
Abstract / Description: While the burden of oral diseases is more on socio-economically disadvantaged groups in India, a paucity of data exists on modifiable risk factors influencing oral health among rural populations in India. This study 1) assessed oral knowledge levels, attitudes, barriers toward seeking professional dental care and utilization of dental care through empirical and anecdotal data; and 2) determined overall caries experience.
Date Issued: 2016-02-01
Identifier: fgcu_ir_000730
Format: Document (PDF)

Title: Assessment of oral health knowledge, practices, and attitudes towards oral health and professional dental care among rural population in the Dominican Republic: a cross-sectional study.
Creator: Kahar, Payal, Tisone, Christine A.
Abstract / Description: Assessing oral health knowledge, attitudes and behaviors provide baseline information for developing health education programs. However, knowledge does not always translate into attitudes and practices and there is disconnect between them. Purpose: This study looked at oral health knowledge, attitudes, behaviors and dental care attendance among adult rural Dominicans, measured the caries prevalence and found the association of knowledge with the study variables.
Date Issued: 2015-01-01
Identifier: fgcu_ir_000728
Format: Document (PDF)

Title: Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC.
Creator: Gupta, Jayanta, Mitra, Nandita, Kanetsky, Peter A., Devaney, Joe, Wing, Maria R., Reilly, Muredach, Shah, Vallabh O., Balakrishnan, Vaidyanathapura S., Guzman, Nicolas J.,...
Show moreGupta, Jayanta, Mitra, Nandita, Kanetsky, Peter A., Devaney, Joe, Wing, Maria R., Reilly, Muredach, Shah, Vallabh O., Balakrishnan, Vaidyanathapura S., Guzman, Nicolas J., Girndt, Matthias, Periera, Brian G., Feldman, Harold I., Kusek, John W., Joffe, Marshall M., Raj, Dominic S.
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Abstract / Description: Increased risk of mortality in patients with CKD has been attributed to inflammation. However, the association between kidney function, albuminuria, and biomarkers of inflammation has not been examined in a large cohort of CKD patients.
Date Issued: 2012-12-01
Identifier: fgcu_ir_000705
Format: Citation

Title: Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study.
Creator: Gupta, Jayanta, Dominic, Elizabeth A., Fink, Jeffrey C., Barrows, Ian R., Townsend, Raymond R., Joffe, Marshall M., Rosas, Sylvia E., Wolman, Melanie, Patel, Samir S., Keane,...
Show moreGupta, Jayanta, Dominic, Elizabeth A., Fink, Jeffrey C., Barrows, Ian R., Townsend, Raymond R., Joffe, Marshall M., Rosas, Sylvia E., Wolman, Melanie, Patel, Samir S., Keane, Martin G., Feldman, Harold I., Kusek, John W., Raj, Dominic S.
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Abstract / Description: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function.
Date Issued: 2015-04-24
Identifier: fgcu_ir_000702
Format: Document (PDF)

Title: Association of HLA-DRB1 genetic variants with the persistence of atopic dermatitis.
Creator: Gupta, Jayanta, Margolis, David J., Mitra, Nandita, Kim, Brian, Hoffstad, Ole, Papadopoulos, Maryte, Wubbenhorst, Bradley, Nathanson, Katherine L., Duke, Jamie L., Monos,...
Show moreGupta, Jayanta, Margolis, David J., Mitra, Nandita, Kim, Brian, Hoffstad, Ole, Papadopoulos, Maryte, Wubbenhorst, Bradley, Nathanson, Katherine L., Duke, Jamie L., Monos, Dimitri, Kamoun, Malek
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Abstract / Description: Atopic dermatitis (AD) is a waxing and waning illness of childhood that is likely caused by interactions between an altered skin barrier and immune dysregulation. The goal of our study was to evaluate the association of DRB1 genetic variants and the persistence of AD using whole exome sequencing and high resolution typing. DRB1 was interrogated based on previous reports that utilized high throughput techniques. We evaluated an ongoing nation-wide long-term cohort of children with AD in which...
Show moreAtopic dermatitis (AD) is a waxing and waning illness of childhood that is likely caused by interactions between an altered skin barrier and immune dysregulation. The goal of our study was to evaluate the association of DRB1 genetic variants and the persistence of AD using whole exome sequencing and high resolution typing. DRB1 was interrogated based on previous reports that utilized high throughput techniques. We evaluated an ongoing nation-wide long-term cohort of children with AD in which patients are asked every 6 months about their medication use and their AD symptoms. In total, 87 African-American and 50 European-American children were evaluated. Genetic association analysis was performed using a software tool focusing on amino acid variable positions shared by HLA-DRB1 alleles covering the antigen presenting domain. Amino acid variations at position 9 (pocket 9), position 26, and position 78 (pocket 4) were marginally associated with the prevalence of AD. However, the odds ratio was 0.30 (0.14, 0.68; p = 0.003) for residue 78, 0.27 (0.10, 0.69; p = 0.006) for residue 26 and not significant for residue 9 with respect to the persistence of AD. In conclusion, amino acid variations at peptide-binding pockets of HLA-DRB1 were associated with the persistence of AD in African-American children.
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Date Issued: 2015-08-01
Identifier: fgcu_ir_000717
Format: Citation

Title: Association of Severe Atopic Dermatitis with month of birth in Armenian pediatric patients.
Creator: Gupta, Jayanta, Sargsyan, Anna, Ghosh, Debajyoti
Abstract / Description: Atopic dermatitis (AD) is a chronic relapsing skin disease which affects 15%‐20% of children worldwide.1 It is also considered as a major risk factor for developing other atopic diseases including food allergy, asthma, and allergic rhinitis later in life—a phenomenon known as the “atopic march.” Multiple factors, including season of birth and associated perinatal environmental conditions, have been known to play important roles in the manifestation of AD.2 Moreover, about 20% of patients with...
Show moreAtopic dermatitis (AD) is a chronic relapsing skin disease which affects 15%‐20% of children worldwide.1 It is also considered as a major risk factor for developing other atopic diseases including food allergy, asthma, and allergic rhinitis later in life—a phenomenon known as the “atopic march.” Multiple factors, including season of birth and associated perinatal environmental conditions, have been known to play important roles in the manifestation of AD.2 Moreover, about 20% of patients with AD have moderate‐to‐severe disease, which is associated with significantly lower quality of life, imposing considerable burden on the nation’s health‐care resources.3 Therefore, studying severe AD patients might be very important in managing overall AD‐related disease burden. The objective of the present study was to identify potential birth season(s) associated with severe AD in Armenian pediatric patients, which would be helpful for the country’s health‐care researchers working toward identifying potential factors associated with severe pediatric AD in Armenia.
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Date Issued: 2018-04-26
Identifier: fgcu_ir_000708
Format: Citation

Title: Associations between Pollen Counts, Pollutants, and Asthma-Related Hospital Admissions in a High-Density Indian Metropolis.
Creator: Gupta, Jayanta, Ghosh, D., Chakraborty, P., Biswas, A., Roy, I., Gupta-Bhattacharya, S.
Abstract / Description: The seasonal pattern of asthma-related hospitalization has often been correlated with ambient allergen/pollutant levels. Objective. To examine the relationship between asthma-related hospital admissions (ARHA) and outdoor pollen, spore, and pollutant levels for adult patients in a densely populated Indian megacity Kolkata. Methods. ARHA data were obtained from two major teaching hospitals of the city. Pollen and spores causing allergic sensitization were identified by skin prick tests (SPTs)...
Show moreThe seasonal pattern of asthma-related hospitalization has often been correlated with ambient allergen/pollutant levels. Objective. To examine the relationship between asthma-related hospital admissions (ARHA) and outdoor pollen, spore, and pollutant levels for adult patients in a densely populated Indian megacity Kolkata. Methods. ARHA data were obtained from two major teaching hospitals of the city. Pollen and spores causing allergic sensitization were identified by skin prick tests (SPTs) among respiratory allergic subjects (N ¼ 1353). Outdoor concentrations of aeroallergens were determined using a Burkard sampler for five consecutive years (2004–2009). Levels of NO2, SO2, suspended particulate matters (SPMs), and respirable particulate matters (RPMs) were made available by West Bengal Pollution Control Board (WBPCB, Government of West Bengal). Poisson multivariate Poisson regression (with adjustments for overdispersion) was used to model the data. Results.We found that ARHA in Kolkata increased with predictable regularity in March and September, while remaining low in January and July. SPT showed highly positive skin reactions with grass/weed and palm pollens in respiratory allergic patients, while Aspergilli spores also evoked good sensitivity. In our regression model, the airborne pollen types, Cheno-Amaranthaceae and Cyperaceae, and the inorganic pollutant, SO2 and RPM, were significantly associated with ARHA (p < .05).
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Date Issued: 2012-09-01
Identifier: fgcu_ir_000722
Format: Citation

Title: Athletic Trainers and the National Health Agenda: Promoting Health Behavior Change.
Creator: Daramola, Charles, Pignataro, Rose, Craddock, Jason
Abstract / Description: The field of athletic training continues to evolve and mature as an integral part of the overall health care team. The National Athletic Trainers' Association and Commission on Athletic Training Education acknowledge and emphasize the importance and responsibility of athletic trainers in meeting the national health agenda through the professional preparation of its current and future practitioners. The United States Department of Health and Human Services, Office of Disease Prevention and...
Show moreThe field of athletic training continues to evolve and mature as an integral part of the overall health care team. The National Athletic Trainers' Association and Commission on Athletic Training Education acknowledge and emphasize the importance and responsibility of athletic trainers in meeting the national health agenda through the professional preparation of its current and future practitioners. The United States Department of Health and Human Services, Office of Disease Prevention and Health Promotion has established priorities for improving the nation's health in a document called Healthy People 2020. Physical activity is a major component for most of the topic areas, positioning athletic trainers to significantly contribute towards achieving the objectives. Despite knowledge regarding the benefits of physical activity, research indicates that less than 25% of American adults meet the recommended guidelines for exercise. Effective strategies to promote exercise adherence must incorporate an expanded perspective of potential barriers and a deeper understanding of other factors that affect the decision to pursue a healthy lifestyle. Further training in social and behavioral theory will improve athletic trainers' ability to communicate with clients by applying concepts that enhance self-efficacy, promote outcome expectancies, and strengthen intentions to actively engage in recommended levels of physical activity. The purpose of this paper is to enhance understanding of fundamental social and behavioral theory, with reference to athletic training, in order to promote its application in athletic training education and practice. This will enable athletic trainers to continue to work towards meeting the goals established by Healthy People 2020.
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Date Issued: 2016-10-01
Identifier: fgcu_ir_000697
Format: Citation

Title: Best Practices in Undergraduate Clinical Laboratory Science Online Education and Effective Use of Educational Technology Tools.
Creator: Zemplinski, Julie
Abstract / Description: This article discusses the best practices of course design and successful delivery of online clinical laboratory science (CLS) courses, and informs educators about the effective use of currently available educational technology tools used to increase student engagement.
Date Issued: 2012-10-01
Identifier: fgcu_ir_000733
Format: Citation

Title: Cannabinoid receptors in the human brain as a pathway as a pathway for the treatment of anxiety, Post-Traumatic stress disorder, and depression.
Creator: Lopez-Whitney, Maria, Marieb College of Health & Human Services
Abstract / Description: Introduction: The endocannabinoid system is widely distributed throughout the brain, with high concentration in areas of mood regulation and emotional processing. This indicates a possible pathway for the treatment of mood disorders, in particular, depression, PTSD, and anxiety.2 This literature review aims to examine and pinpoint possible targets within the endocannabinoid system as a pathway for the treatment of depression, PTSD, and anxiety. Methods: This literature review presents an...
Show moreIntroduction: The endocannabinoid system is widely distributed throughout the brain, with high concentration in areas of mood regulation and emotional processing. This indicates a possible pathway for the treatment of mood disorders, in particular, depression, PTSD, and anxiety.2 This literature review aims to examine and pinpoint possible targets within the endocannabinoid system as a pathway for the treatment of depression, PTSD, and anxiety. Methods: This literature review presents an overview of studies where specific portions of the endocannabinoid system have been tested on either animals or humans as a target in the treatment of PTSD, anxiety, and depression. Discussion: The CB1 receptor has a role in the regulation of depression and anxiety, and the CB1 receptor agonists HU210, rimonabant, and AM251 are promising treatments for depression and anxiety. However, the endocannabinoid degradative pathway FAAH, AEA, and 2-AG are questionable targets in anxiety since certain doses could cause an increase in anxiety.1,4,5 Endocannabinoid system agonist show a promising treatment pathway for PTSD that encompasses the reduction of most symptoms related to the disorder, but only nabilone has been studied. Conclusion: Most studies indicate that using CB1 receptor agonists and the degradative pathway, there is significant reduction in depression and anxiety. However, most of the studies are animal based, which is why there needs to be a transition to human studies in order to develop therapeutic agents. In addition, the role of AEA in anxiety needs to be further researched as a possible pathway with animal studies. Also, while the endocannabinoid agonists show a promising comprehensive treatment for PTSD, more studies must be done to support the role of the endocannabinoid system in the treatment of PTSD.
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Date Issued: 2019-12-16
Identifier: fgcu_ETD_0314
Format: Document (PDF)

Title: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.
Creator: Joshi, Anjali, Punke, Erin B., Sedano, Melina, Beauchamp, Bethany, Patel, Rima, Hossenlopp, Cassady, Alozie, Ogechika K., Gupta, Jayanta, Mukherjee, Debabrata, Garg, Himanshu
Abstract / Description: CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA...
Show moreCCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients. Interestingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic patients. In normal individuals, the CRPA correlated with the number of CCR5+ CD4+ T cells in the peripheral blood suggesting an effect on CCR5 expression. In a subset of high viremic patients harboring R5 tropic HIV, there was a strong correlation between CCR5 CRPA and both CD4 counts and CD4 T cell apoptosis. Our study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients. Furthermore, assigning CRPAs to each patient is a new method of translating genotype to phenotype.
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Date Issued: 2017-12-22
Identifier: 10.1038/s41598-017-00192-x, fgcu_ir_000078, http://www.nature.com/articles/s41598-017-00192-x
Format: Citation

Title: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.
Creator: Gupta, Jayanta, Joshi, Anjali, Punke, Erin B., Sedano, Melina, Beauchamp, Bethany, Patel, Rima, Hossenlopp, Cassady, Alozie, Ogechika K., Mukherjee, Debabrata, Garg, Himanshu
Abstract / Description: CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA...
Show moreCCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients. Interestingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic patients. In normal individuals, the CRPA correlated with the number of CCR5+ CD4+ T cells in the peripheral blood suggesting an effect on CCR5 expression. In a subset of high viremic patients harboring R5 tropic HIV, there was a strong correlation between CCR5 CRPA and both CD4 counts and CD4 T cell apoptosis. Our study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients. Furthermore, assigning CRPAs to each patient is a new method of translating genotype to phenotype.
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Date Issued: 2017-03-27
Identifier: fgcu_ir_000710
Format: Document (PDF)

Title: Comparing working role values of employed and unemployed Clubhouse members.
Creator: Glacken, Joan, Gregitis, Susan, Julian, Chris, Underwood, Kristie
Abstract / Description: Examine the impact of the Clubhouse Model of Vocational Rehabilitation by comparing the roles values of employed and unemployed members. It is a model of psychiatric rehabilitation and community support, which emphasizes the importance of work as a major re-integrative force for Clubhouse members. Participants: Sixty Clubhouse members consisting of 31 employed members and 29 non-employed members. Methods: A convenience sample of sixty participants completed the Role Checklist (Revised) ...
Show moreExamine the impact of the Clubhouse Model of Vocational Rehabilitation by comparing the roles values of employed and unemployed members. It is a model of psychiatric rehabilitation and community support, which emphasizes the importance of work as a major re-integrative force for Clubhouse members. Participants: Sixty Clubhouse members consisting of 31 employed members and 29 non-employed members. Methods: A convenience sample of sixty participants completed the Role Checklist (Revised) (Oakley, Kielhofner, Barris, and Klinger-Reichler, 1988), the Maryland Addiction Questionnaire Short-Form (O'Donnell, 1997), and the Historical Background Survey (Gregitis, 2003). The study was completed at an ICCD certified Clubhouse in the United States. Results: Results showed that there was no significant difference in the working role values of employed and unemployed participants. However, there was a significant difference in resistance to treatment of substance use by employed and unemployed participants. Conclusions: Volition and motivation of the employed Clubhouse members was higher when seeking work and pursuing life roles outside the Clubhouse environment. Unemployed Clubhouse members derived personal satisfaction and volition in the work-ordered day within the clubhouse setting. Further research should include verification, with a larger sample, of the importance of the working role in relation to mental health.
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Date Issued: 2010-01-01
Identifier: fgcu_ir_000698
Format: Citation

Title: Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D‐Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes.
Creator: Gupta, Jayanta, Denburg, Michelle R., Hoofnagle, Andrew N., Sayed, Samir, Boer, Ian H., Appel, Lawrence J., Durazo-Arvizu, Ramon, Whitehead, Krista, Feldman, Harold I., Leonard,...
Show moreGupta, Jayanta, Denburg, Michelle R., Hoofnagle, Andrew N., Sayed, Samir, Boer, Ian H., Appel, Lawrence J., Durazo-Arvizu, Ramon, Whitehead, Krista, Feldman, Harold I., Leonard, Mary B.
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Abstract / Description: Studies using vitamin D‐binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years. Combinations of two single‐nucleotide polymorphisms (SNPs) produce three major DBP isoforms (Gc1f, Gc1s, and Gc2). A recent study showed that DBP concentrations quantified by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) did not differ by race, whereas a widely used monoclonal enzyme‐linked immunosorbent assay (ELISA) quantified DBP...
Show moreStudies using vitamin D‐binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years. Combinations of two single‐nucleotide polymorphisms (SNPs) produce three major DBP isoforms (Gc1f, Gc1s, and Gc2). A recent study showed that DBP concentrations quantified by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) did not differ by race, whereas a widely used monoclonal enzyme‐linked immunosorbent assay (ELISA) quantified DBP differentially by isoform, yielding significantly lower DBP concentrations in black versus white individuals. We compared measurements of serum DBP using a monoclonal ELISA, a polyclonal ELISA, and LC‐MS/MS in 125 participants in the Chronic Renal Insufficiency Cohort (CRIC). Serum free and bioavailable 25OHD were calculated based on DBP concentrations from these three assays in homozygous participants, and race differences were compared. We confirmed that the monoclonal ELISA quantifies DBP differentially by isoform and showed that the polyclonal ELISA is not subject to this bias. Whereas ≤9% of the variability in DBP concentrations quantified using either LC‐MS/MS or the polyclonal ELISA was explained by genotype, 85% of the variability in the monoclonal ELISA‐based measures was explained by genotype. DBP concentrations measured by the monoclonal ELISA were disproportionately lower than LC‐MS/MS‐based results for Gc1f homozygotes (median difference –67%; interquartile range [IQR] –71%, –64%), 95% of whom were black. In contrast, the polyclonal ELISA yielded consistently and similarly higher measurements of DBP than LC‐MS/MS, irrespective of genotype, with a median percent difference of +50% (IQR +33%, +65%). Contrary to findings using the monoclonal ELISA, DBP concentrations did not differ by race, and free and bioavailable 25OHD were significantly lower in black versus white participants based on both the polyclonal ELISA and LC‐MS/MS, consistent with their lower total 25OHD. Future studies of DBP and free or bioavailable vitamin D metabolites should employ DBP assays that are not biased by DBP genotype. © 2016 American Society for Bone and Mineral Research.
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Date Issued: 2016-03-08
Identifier: fgcu_ir_000715
Format: Citation

Title: Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the Chronic Renal Insufficiency Cohort study.
Creator: Gupta, Jayanta, Margolis, David J., Thom, Stephen R., Townsend, Raymond R., Kanetsky, Peter, Hoffstad, Ole, Papadopoulos, Maryte, Fischer, Michael, Schelling, Jeffrey R., Mitra,...
Show moreGupta, Jayanta, Margolis, David J., Thom, Stephen R., Townsend, Raymond R., Kanetsky, Peter, Hoffstad, Ole, Papadopoulos, Maryte, Fischer, Michael, Schelling, Jeffrey R., Mitra, Nandita
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Abstract / Description: Lower extremity amputation ( LEA) is a life-altering complication of diabetes. The goal of our study was to investigate the possibility that genetic variation in neuronal nitric oxide synthase associated protein ( NOS1AP ) is associated with LEA and diabetic peripheral neuropathy ( DPN). Our work used data from the Chronic Renal Insufficiency Cohort ( CRIC) study. CRIC is a multicenter investigation undertaken to pursue the relationship between chronic renal insufficiency and cardiovascular...
Show moreLower extremity amputation ( LEA) is a life-altering complication of diabetes. The goal of our study was to investigate the possibility that genetic variation in neuronal nitric oxide synthase associated protein ( NOS1AP ) is associated with LEA and diabetic peripheral neuropathy ( DPN). Our work used data from the Chronic Renal Insufficiency Cohort ( CRIC) study. CRIC is a multicenter investigation undertaken to pursue the relationship between chronic renal insufficiency and cardiovascular disease. We evaluated 3,040 CRIC study subjects; 1,490 individuals were African Americans and 1,550 were whites. LEA occurred in 162 (5.3%) subjects, 93 (6.2%) of African Americans and 69 (4.4%) of whites. In whites, NOS1AP single nucleotide polymorphism rs1963645 was most strongly associated with LEA (1.73 [1.23, 2.44]). In African Americans three NOS1AP single nucleotide polymorphisms were associated with LEA: rs6659759 (1.65 [1.21, 2.24]); rs16849113 (1.58 [1.16, 2.14]); rs880296 (1.54 [1.14, 2.10]). We tested a subset of 100 CRIC participants for DPN using Semmes- Weinstein filaments. DPN in those with diabetes was associated with rs1963645 (16.97 [2.38, 120.97]) in whites and rs16849113 and rs6659759 (3.62 [1.11, 11.83] and 3.02 [0.82, 11.12], respectively) in African Americans. In conclusion, this is one of the first studies to show that NOS1AP gene variants are associated with DPN and LEA.
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Date Issued: 2013-01-01
Identifier: fgcu_ir_000721
Format: Citation

Title: Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children.
Creator: Gupta, Jayanta, Baye, Tesfaye M., Kovacic, Melinda Butsch, Biagini Myers, Jocelyn M., Martin, Lisa J., Lindsey, Mark, Patterson, Tia L., Hua, He, Ericksen, Mark B., Tsoras, Anna...
Show moreGupta, Jayanta, Baye, Tesfaye M., Kovacic, Melinda Butsch, Biagini Myers, Jocelyn M., Martin, Lisa J., Lindsey, Mark, Patterson, Tia L., Hua, He, Ericksen, Mark B., Tsoras, Anna M., Lindsley, Andrew, Rothenberg, Marc E., Wills-Karp, Marsha, Eissa, N. Tony, Borish, Larry, Khurana Hershey, Gurjit K.
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Abstract / Description: Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between...
Show moreCandidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry.
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Date Issued: 2011-02-28
Identifier: fgcu_ir_000725
Format: Document (PDF)

Title: Evaluating Trust and Its Timeline in Medical Practitioners.
Creator: Ciccone, Alexandra, Marieb College of Health & Human Services
Abstract / Description: Medicare and Medicaid created the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey to capture hospital care information from the patient’s perspective. Patient satisfaction scores are tied to hospital reimbursement. HCAHPS doesn’t evaluate if patients trust their provider. We asked this question along with when and why patient-provider trust was established. 152 (95.6%) of the 159 patients interviewed trusted their medical provider, only seven (4.4%) did not....
Show moreMedicare and Medicaid created the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey to capture hospital care information from the patient’s perspective. Patient satisfaction scores are tied to hospital reimbursement. HCAHPS doesn’t evaluate if patients trust their provider. We asked this question along with when and why patient-provider trust was established. 152 (95.6%) of the 159 patients interviewed trusted their medical provider, only seven (4.4%) did not. It is of utmost importance for providers to make a good impression during their initial patient encounter, as 85.5% of patients said trust was developed at their first interaction. A combination of communication skills and time spent ranked highest on patient’s reasoning for why patient-provider trust was or was not developed. This study highlights the need for all medical practitioners to enhance their ability to communicate effectively in order to better influence a patient’s satisfaction and positive perception of their care.
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Date Issued: 2019-12-13
Identifier: fgcu_ETD_0317
Format: Document (PDF)

Atopic dermatitis. (9)	+ -
Medical care (6)	+ -
Asthma. (5)	+ -
Chronic kidney disease (5)	+ -
African American (4)	+ -

filaggrin (4)	+ -
Epidemiology. (3)	+ -
Genetic epidemiology. (3)	+ -
Genetics. (3)	+ -
Oral Health (3)	+ -
atopy (3)	+ -
Amputation. (2)	+ -
End-stage renal disease (2)	+ -
Inflammation. (2)	+ -
-omics (1)	+ -
Academic Medical Centers. (1)	+ -
Age differences (1)	+ -
Albuminuria. (1)	+ -
Allelopathy. (1)	+ -
Allergens. (1)	+ -
Allergic rhinitis (1)	+ -
Allergic sensitization (1)	+ -
Antipsychotic drugs (1)	+ -
Anxiety (1)	+ -
Appendicitis (1)	+ -
Atopic march (1)	+ -
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