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Title: Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates.
Creator: Gupta, Jayanta, Stevenson, Michelle D., Sellins, Stacey, Grube, Emilie, Schroer, Kathy, Wang, Ning, Khurana Hershey, Gurjit K.
Abstract / Description: Allergic sensitization is very prevalent and often precedes the development of allergic disease. This study examined the association of race with allergic sensitization among healthy children with no family history of atopy.
Date Issued: 2007-08-01
Identifier: fgcu_ir_000727
Format: Citation

Title: Airborne microorganisms, endotoxin, and (1->3)-β-Dglucan exposure in greenhouses and assessment of respiratory symptoms among workers.
Creator: Gupta, Jayanta, Adhikari, Atin, Wilkins, III, John R., Olds, Rolanda L., Indugula, Reshmi, Cho, Kyungmin J., Li, Chunlei, Yermakov, Michael
Abstract / Description: Greenhouse operations are an important sector of the horticulture industry, also known as the Green Industry. The objectives of this study were (i) to investigate exposure levels to airborne culturable fungi, bacteria (total culturable bacteria and actinomycetes), endotoxin, and (1→3)-β-D-glucan in three Midwest greenhouses during summer and winter using multiple exposure assessment methods; (ii) characterize the load of microorganisms on greenhouse floors and determine potential microbial...
Show moreGreenhouse operations are an important sector of the horticulture industry, also known as the Green Industry. The objectives of this study were (i) to investigate exposure levels to airborne culturable fungi, bacteria (total culturable bacteria and actinomycetes), endotoxin, and (1→3)-β-D-glucan in three Midwest greenhouses during summer and winter using multiple exposure assessment methods; (ii) characterize the load of microorganisms on greenhouse floors and determine potential microbial source strengths of the floors for aerosolizing microbial biocontaminants, and (iii) to estimate the prevalence of rhinitis, wheezing, asthma, and other respiratory symptoms/conditions among greenhouse workers.
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Date Issued: 2010-12-20
Identifier: fgcu_ir_000726
Format: Citation

Title: Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC.
Creator: Gupta, Jayanta, Mitra, Nandita, Kanetsky, Peter A., Devaney, Joe, Wing, Maria R., Reilly, Muredach, Shah, Vallabh O., Balakrishnan, Vaidyanathapura S., Guzman, Nicolas J.,...
Show moreGupta, Jayanta, Mitra, Nandita, Kanetsky, Peter A., Devaney, Joe, Wing, Maria R., Reilly, Muredach, Shah, Vallabh O., Balakrishnan, Vaidyanathapura S., Guzman, Nicolas J., Girndt, Matthias, Periera, Brian G., Feldman, Harold I., Kusek, John W., Joffe, Marshall M., Raj, Dominic S.
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Abstract / Description: Increased risk of mortality in patients with CKD has been attributed to inflammation. However, the association between kidney function, albuminuria, and biomarkers of inflammation has not been examined in a large cohort of CKD patients.
Date Issued: 2012-12-01
Identifier: fgcu_ir_000705
Format: Citation

Title: Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study.
Creator: Gupta, Jayanta, Dominic, Elizabeth A., Fink, Jeffrey C., Barrows, Ian R., Townsend, Raymond R., Joffe, Marshall M., Rosas, Sylvia E., Wolman, Melanie, Patel, Samir S., Keane,...
Show moreGupta, Jayanta, Dominic, Elizabeth A., Fink, Jeffrey C., Barrows, Ian R., Townsend, Raymond R., Joffe, Marshall M., Rosas, Sylvia E., Wolman, Melanie, Patel, Samir S., Keane, Martin G., Feldman, Harold I., Kusek, John W., Raj, Dominic S.
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Abstract / Description: Left ventricular hypertrophy (LVH) and myocardial contractile dysfunction are independent predictors of mortality in patients with chronic kidney disease (CKD). The association between inflammatory biomarkers and cardiac geometry has not yet been studied in a large cohort of CKD patients with a wide range of kidney function.
Date Issued: 2015-04-24
Identifier: fgcu_ir_000702
Format: Document (PDF)

Title: Association of HLA-DRB1 genetic variants with the persistence of atopic dermatitis.
Creator: Gupta, Jayanta, Margolis, David J., Mitra, Nandita, Kim, Brian, Hoffstad, Ole, Papadopoulos, Maryte, Wubbenhorst, Bradley, Nathanson, Katherine L., Duke, Jamie L., Monos,...
Show moreGupta, Jayanta, Margolis, David J., Mitra, Nandita, Kim, Brian, Hoffstad, Ole, Papadopoulos, Maryte, Wubbenhorst, Bradley, Nathanson, Katherine L., Duke, Jamie L., Monos, Dimitri, Kamoun, Malek
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Abstract / Description: Atopic dermatitis (AD) is a waxing and waning illness of childhood that is likely caused by interactions between an altered skin barrier and immune dysregulation. The goal of our study was to evaluate the association of DRB1 genetic variants and the persistence of AD using whole exome sequencing and high resolution typing. DRB1 was interrogated based on previous reports that utilized high throughput techniques. We evaluated an ongoing nation-wide long-term cohort of children with AD in which...
Show moreAtopic dermatitis (AD) is a waxing and waning illness of childhood that is likely caused by interactions between an altered skin barrier and immune dysregulation. The goal of our study was to evaluate the association of DRB1 genetic variants and the persistence of AD using whole exome sequencing and high resolution typing. DRB1 was interrogated based on previous reports that utilized high throughput techniques. We evaluated an ongoing nation-wide long-term cohort of children with AD in which patients are asked every 6 months about their medication use and their AD symptoms. In total, 87 African-American and 50 European-American children were evaluated. Genetic association analysis was performed using a software tool focusing on amino acid variable positions shared by HLA-DRB1 alleles covering the antigen presenting domain. Amino acid variations at position 9 (pocket 9), position 26, and position 78 (pocket 4) were marginally associated with the prevalence of AD. However, the odds ratio was 0.30 (0.14, 0.68; p = 0.003) for residue 78, 0.27 (0.10, 0.69; p = 0.006) for residue 26 and not significant for residue 9 with respect to the persistence of AD. In conclusion, amino acid variations at peptide-binding pockets of HLA-DRB1 were associated with the persistence of AD in African-American children.
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Date Issued: 2015-08-01
Identifier: fgcu_ir_000717
Format: Citation

Title: Association of Severe Atopic Dermatitis with month of birth in Armenian pediatric patients.
Creator: Gupta, Jayanta, Sargsyan, Anna, Ghosh, Debajyoti
Abstract / Description: Atopic dermatitis (AD) is a chronic relapsing skin disease which affects 15%‐20% of children worldwide.1 It is also considered as a major risk factor for developing other atopic diseases including food allergy, asthma, and allergic rhinitis later in life—a phenomenon known as the “atopic march.” Multiple factors, including season of birth and associated perinatal environmental conditions, have been known to play important roles in the manifestation of AD.2 Moreover, about 20% of patients with...
Show moreAtopic dermatitis (AD) is a chronic relapsing skin disease which affects 15%‐20% of children worldwide.1 It is also considered as a major risk factor for developing other atopic diseases including food allergy, asthma, and allergic rhinitis later in life—a phenomenon known as the “atopic march.” Multiple factors, including season of birth and associated perinatal environmental conditions, have been known to play important roles in the manifestation of AD.2 Moreover, about 20% of patients with AD have moderate‐to‐severe disease, which is associated with significantly lower quality of life, imposing considerable burden on the nation’s health‐care resources.3 Therefore, studying severe AD patients might be very important in managing overall AD‐related disease burden. The objective of the present study was to identify potential birth season(s) associated with severe AD in Armenian pediatric patients, which would be helpful for the country’s health‐care researchers working toward identifying potential factors associated with severe pediatric AD in Armenia.
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Date Issued: 2018-04-26
Identifier: fgcu_ir_000708
Format: Citation

Title: Associations between Pollen Counts, Pollutants, and Asthma-Related Hospital Admissions in a High-Density Indian Metropolis.
Creator: Gupta, Jayanta, Ghosh, D., Chakraborty, P., Biswas, A., Roy, I., Gupta-Bhattacharya, S.
Abstract / Description: The seasonal pattern of asthma-related hospitalization has often been correlated with ambient allergen/pollutant levels. Objective. To examine the relationship between asthma-related hospital admissions (ARHA) and outdoor pollen, spore, and pollutant levels for adult patients in a densely populated Indian megacity Kolkata. Methods. ARHA data were obtained from two major teaching hospitals of the city. Pollen and spores causing allergic sensitization were identified by skin prick tests (SPTs)...
Show moreThe seasonal pattern of asthma-related hospitalization has often been correlated with ambient allergen/pollutant levels. Objective. To examine the relationship between asthma-related hospital admissions (ARHA) and outdoor pollen, spore, and pollutant levels for adult patients in a densely populated Indian megacity Kolkata. Methods. ARHA data were obtained from two major teaching hospitals of the city. Pollen and spores causing allergic sensitization were identified by skin prick tests (SPTs) among respiratory allergic subjects (N ¼ 1353). Outdoor concentrations of aeroallergens were determined using a Burkard sampler for five consecutive years (2004–2009). Levels of NO2, SO2, suspended particulate matters (SPMs), and respirable particulate matters (RPMs) were made available by West Bengal Pollution Control Board (WBPCB, Government of West Bengal). Poisson multivariate Poisson regression (with adjustments for overdispersion) was used to model the data. Results.We found that ARHA in Kolkata increased with predictable regularity in March and September, while remaining low in January and July. SPT showed highly positive skin reactions with grass/weed and palm pollens in respiratory allergic patients, while Aspergilli spores also evoked good sensitivity. In our regression model, the airborne pollen types, Cheno-Amaranthaceae and Cyperaceae, and the inorganic pollutant, SO2 and RPM, were significantly associated with ARHA (p < .05).
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Date Issued: 2012-09-01
Identifier: fgcu_ir_000722
Format: Citation

Title: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.
Creator: Joshi, Anjali, Punke, Erin B., Sedano, Melina, Beauchamp, Bethany, Patel, Rima, Hossenlopp, Cassady, Alozie, Ogechika K., Gupta, Jayanta, Mukherjee, Debabrata, Garg, Himanshu
Abstract / Description: CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA...
Show moreCCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients. Interestingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic patients. In normal individuals, the CRPA correlated with the number of CCR5+ CD4+ T cells in the peripheral blood suggesting an effect on CCR5 expression. In a subset of high viremic patients harboring R5 tropic HIV, there was a strong correlation between CCR5 CRPA and both CD4 counts and CD4 T cell apoptosis. Our study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients. Furthermore, assigning CRPAs to each patient is a new method of translating genotype to phenotype.
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Date Issued: 2017-12-22
Identifier: 10.1038/s41598-017-00192-x, fgcu_ir_000078, http://www.nature.com/articles/s41598-017-00192-x
Format: Citation

Title: CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.
Creator: Gupta, Jayanta, Joshi, Anjali, Punke, Erin B., Sedano, Melina, Beauchamp, Bethany, Patel, Rima, Hossenlopp, Cassady, Alozie, Ogechika K., Mukherjee, Debabrata, Garg, Himanshu
Abstract / Description: CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA...
Show moreCCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients. Interestingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic patients. In normal individuals, the CRPA correlated with the number of CCR5+ CD4+ T cells in the peripheral blood suggesting an effect on CCR5 expression. In a subset of high viremic patients harboring R5 tropic HIV, there was a strong correlation between CCR5 CRPA and both CD4 counts and CD4 T cell apoptosis. Our study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients. Furthermore, assigning CRPAs to each patient is a new method of translating genotype to phenotype.
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Date Issued: 2017-03-27
Identifier: fgcu_ir_000710
Format: Document (PDF)

Title: Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D‐Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes.
Creator: Gupta, Jayanta, Denburg, Michelle R., Hoofnagle, Andrew N., Sayed, Samir, Boer, Ian H., Appel, Lawrence J., Durazo-Arvizu, Ramon, Whitehead, Krista, Feldman, Harold I., Leonard,...
Show moreGupta, Jayanta, Denburg, Michelle R., Hoofnagle, Andrew N., Sayed, Samir, Boer, Ian H., Appel, Lawrence J., Durazo-Arvizu, Ramon, Whitehead, Krista, Feldman, Harold I., Leonard, Mary B.
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Abstract / Description: Studies using vitamin D‐binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years. Combinations of two single‐nucleotide polymorphisms (SNPs) produce three major DBP isoforms (Gc1f, Gc1s, and Gc2). A recent study showed that DBP concentrations quantified by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) did not differ by race, whereas a widely used monoclonal enzyme‐linked immunosorbent assay (ELISA) quantified DBP...
Show moreStudies using vitamin D‐binding protein (DBP) concentrations to estimate free and bioavailable vitamin D have increased dramatically in recent years. Combinations of two single‐nucleotide polymorphisms (SNPs) produce three major DBP isoforms (Gc1f, Gc1s, and Gc2). A recent study showed that DBP concentrations quantified by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) did not differ by race, whereas a widely used monoclonal enzyme‐linked immunosorbent assay (ELISA) quantified DBP differentially by isoform, yielding significantly lower DBP concentrations in black versus white individuals. We compared measurements of serum DBP using a monoclonal ELISA, a polyclonal ELISA, and LC‐MS/MS in 125 participants in the Chronic Renal Insufficiency Cohort (CRIC). Serum free and bioavailable 25OHD were calculated based on DBP concentrations from these three assays in homozygous participants, and race differences were compared. We confirmed that the monoclonal ELISA quantifies DBP differentially by isoform and showed that the polyclonal ELISA is not subject to this bias. Whereas ≤9% of the variability in DBP concentrations quantified using either LC‐MS/MS or the polyclonal ELISA was explained by genotype, 85% of the variability in the monoclonal ELISA‐based measures was explained by genotype. DBP concentrations measured by the monoclonal ELISA were disproportionately lower than LC‐MS/MS‐based results for Gc1f homozygotes (median difference –67%; interquartile range [IQR] –71%, –64%), 95% of whom were black. In contrast, the polyclonal ELISA yielded consistently and similarly higher measurements of DBP than LC‐MS/MS, irrespective of genotype, with a median percent difference of +50% (IQR +33%, +65%). Contrary to findings using the monoclonal ELISA, DBP concentrations did not differ by race, and free and bioavailable 25OHD were significantly lower in black versus white participants based on both the polyclonal ELISA and LC‐MS/MS, consistent with their lower total 25OHD. Future studies of DBP and free or bioavailable vitamin D metabolites should employ DBP assays that are not biased by DBP genotype. © 2016 American Society for Bone and Mineral Research.
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Date Issued: 2016-03-08
Identifier: fgcu_ir_000715
Format: Citation

Title: Diabetes, lower extremity amputation, loss of protective sensation, and neuronal nitric oxide synthase associated protein in the Chronic Renal Insufficiency Cohort study.
Creator: Gupta, Jayanta, Margolis, David J., Thom, Stephen R., Townsend, Raymond R., Kanetsky, Peter, Hoffstad, Ole, Papadopoulos, Maryte, Fischer, Michael, Schelling, Jeffrey R., Mitra,...
Show moreGupta, Jayanta, Margolis, David J., Thom, Stephen R., Townsend, Raymond R., Kanetsky, Peter, Hoffstad, Ole, Papadopoulos, Maryte, Fischer, Michael, Schelling, Jeffrey R., Mitra, Nandita
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Abstract / Description: Lower extremity amputation ( LEA) is a life-altering complication of diabetes. The goal of our study was to investigate the possibility that genetic variation in neuronal nitric oxide synthase associated protein ( NOS1AP ) is associated with LEA and diabetic peripheral neuropathy ( DPN). Our work used data from the Chronic Renal Insufficiency Cohort ( CRIC) study. CRIC is a multicenter investigation undertaken to pursue the relationship between chronic renal insufficiency and cardiovascular...
Show moreLower extremity amputation ( LEA) is a life-altering complication of diabetes. The goal of our study was to investigate the possibility that genetic variation in neuronal nitric oxide synthase associated protein ( NOS1AP ) is associated with LEA and diabetic peripheral neuropathy ( DPN). Our work used data from the Chronic Renal Insufficiency Cohort ( CRIC) study. CRIC is a multicenter investigation undertaken to pursue the relationship between chronic renal insufficiency and cardiovascular disease. We evaluated 3,040 CRIC study subjects; 1,490 individuals were African Americans and 1,550 were whites. LEA occurred in 162 (5.3%) subjects, 93 (6.2%) of African Americans and 69 (4.4%) of whites. In whites, NOS1AP single nucleotide polymorphism rs1963645 was most strongly associated with LEA (1.73 [1.23, 2.44]). In African Americans three NOS1AP single nucleotide polymorphisms were associated with LEA: rs6659759 (1.65 [1.21, 2.24]); rs16849113 (1.58 [1.16, 2.14]); rs880296 (1.54 [1.14, 2.10]). We tested a subset of 100 CRIC participants for DPN using Semmes- Weinstein filaments. DPN in those with diabetes was associated with rs1963645 (16.97 [2.38, 120.97]) in whites and rs16849113 and rs6659759 (3.62 [1.11, 11.83] and 3.02 [0.82, 11.12], respectively) in African Americans. In conclusion, this is one of the first studies to show that NOS1AP gene variants are associated with DPN and LEA.
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Date Issued: 2013-01-01
Identifier: fgcu_ir_000721
Format: Citation

Title: Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children.
Creator: Gupta, Jayanta, Baye, Tesfaye M., Kovacic, Melinda Butsch, Biagini Myers, Jocelyn M., Martin, Lisa J., Lindsey, Mark, Patterson, Tia L., Hua, He, Ericksen, Mark B., Tsoras, Anna...
Show moreGupta, Jayanta, Baye, Tesfaye M., Kovacic, Melinda Butsch, Biagini Myers, Jocelyn M., Martin, Lisa J., Lindsey, Mark, Patterson, Tia L., Hua, He, Ericksen, Mark B., Tsoras, Anna M., Lindsley, Andrew, Rothenberg, Marc E., Wills-Karp, Marsha, Eissa, N. Tony, Borish, Larry, Khurana Hershey, Gurjit K.
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Abstract / Description: Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between...
Show moreCandidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry.
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Date Issued: 2011-02-28
Identifier: fgcu_ir_000725
Format: Document (PDF)

Title: Exome Sequencing of Filaggrin and Related Genes in African-American Children with Atopic Dermatitis.
Creator: Gupta, Jayanta, Margolis, David J., Apter, Andrea J., Hoffstad, Ole, Papadopoulos, Maryte, Rebbeck, Tim R., Wubbenhorst, Bradley, Mitra, Nandita
Abstract / Description: The goal of this study was to identify stop-gain variants in FLG and closely related genes in African Americans with AD from the Pediatric Eczema Elective Registry (PEER; Margolis et al., 2012 ). From this cohort we randomly selected 60 subjects for whole-exome sequencing to ensure sufficient power to detect variants with a minor allelic frequency (MAF) of greater than 3%. Sequencing was performed by Ambry Genetics (Aliso Viejo, CA) using whole exome–targeted enrichment by Agilent...
Show moreThe goal of this study was to identify stop-gain variants in FLG and closely related genes in African Americans with AD from the Pediatric Eczema Elective Registry (PEER; Margolis et al., 2012 ). From this cohort we randomly selected 60 subjects for whole-exome sequencing to ensure sufficient power to detect variants with a minor allelic frequency (MAF) of greater than 3%. Sequencing was performed by Ambry Genetics (Aliso Viejo, CA) using whole exome–targeted enrichment by Agilent SureSelectXT Human All Exon 50Mb kit. Quality assessment revealed that most samples were above 50% on target and mean coverage per gene was excellent. The libraries were indexed using 100 base paired ends and processed using Illumina HiSeq2000 at × 100 coverage per exon. Data were assessed using a pipeline generated at the University of Pennsylvania based on the best practices protocol from the Broad Institute (Cambridge, MA). This report focused on stop-gain mutations of exon 3 (i.e., loss-of-function mutations) in the SFTP genes because of their likely functional relevance (Marenholz et al., 2011 Brown and McLean, 2012 ; Henry et al., 2012). Taqman allelic discrimination assays were created for any newly identified FLG loss-of-function mutations, which were then used to genotype an additional random sample of 100 African-American PEER children.
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Date Issued: 2014-08-01
Identifier: fgcu_ir_000703
Format: Citation

Title: Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects.
Creator: Gupta, Jayanta, Margolis, David J., Apter, Andrea J., Ganguly, Tapan, Hoffstad, Ole, Papadopoulos, Maryte, Rebbeck, Tim R., Mitra, Nandita
Abstract / Description: Atopic dermatitis (AD) is a common skin disease characterized by recurrent episodes of itching. Genetic variation associated with the persistence of AD has not been described for African American subjects.
Date Issued: 2014-03-01
Identifier: fgcu_ir_000704
Format: Citation

Title: Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma.
Creator: Gupta, Jayanta, Martin, Lisa J., Jyothula, Soma S. S. K., Butsch Kovacic, Melinda, Biagini Myers, Jocelyn M., Patterson, Tia L., Ericksen, Mark B., He, Hua, Gibson, Aaron M.,...
Show moreGupta, Jayanta, Martin, Lisa J., Jyothula, Soma S. S. K., Butsch Kovacic, Melinda, Biagini Myers, Jocelyn M., Patterson, Tia L., Ericksen, Mark B., He, Hua, Gibson, Aaron M., Baye, Tesfaye M., Amirisetty, Sushil, Tsoras, Anna M., Sha, Youbao, Eissa, N. Tony, Khurana Hershey, Gurjit K.
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Abstract / Description: Autophagy is a cellular process directed at eliminating or recycling cellular proteins. Recently, the autophagy pathway has been implicated in immune dysfunction, the pathogenesis of inflammatory disorders, and response to viral infection. Associations between two genes in the autophagy pathway, ATG5 and ATG7, with childhood asthma were investigated.
Date Issued: 2012-04-20
Identifier: fgcu_ir_000706
Format: Document (PDF)

Title: Genetic African Ancestry and Markers of Mineral Metabolism in CKD.
Creator: Gupta, Jayanta, Gutierrez, Orlando M., Parsa, Afshin, Isakova, Tamara, Scialla, Julia J., Chen, Jing, Flack, John M., Nessel, Lisa C., Bellovich, Keith A., Steigerwalt, Susan,...
Show moreGupta, Jayanta, Gutierrez, Orlando M., Parsa, Afshin, Isakova, Tamara, Scialla, Julia J., Chen, Jing, Flack, John M., Nessel, Lisa C., Bellovich, Keith A., Steigerwalt, Susan, Sondheimer, James H., Wright Jr, Jackson T., Feldman, Harold I., Kusek, John W., Lash, James P., Wolf, Myles
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Abstract / Description: Disorders of mineral metabolism are more common in African Americans with CKD than in EuropeanAmericanswith CKD. Previous studies have focused on the differences inmineral metabolism by self-reported race, making it difficult to delineate the importance of environmental compared with biologic factors.
Date Issued: 2016-04-01
Identifier: fgcu_ir_000716
Format: Citation

Title: Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.
Creator: Gupta, Jayanta, Parsa, Afshin, Salimi, Shabnam, Kanetsky, Peter A., Xiao, Rui, Mitra, Nandita, Limou, Sophie, Xie, Dawei, Anderson, Amanda Hyre, Ojo, Akinlolu, Kusek, John W.,...
Show moreGupta, Jayanta, Parsa, Afshin, Salimi, Shabnam, Kanetsky, Peter A., Xiao, Rui, Mitra, Nandita, Limou, Sophie, Xie, Dawei, Anderson, Amanda Hyre, Ojo, Akinlolu, Kusek, John W., Lora, Claudia M., Hamm, L. Lee, He, Jiang, Sandholm, Niina, Jeff, Janina, Raj, Dominic E., Böger, Carsten A., Bottinger, Erwin
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Abstract / Description: The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome–wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms ...
Show moreThe rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome–wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of P<1×10−6 for association with eGFR slope were selected as candidates for follow-up and secondarily tested for association with proteinuria and time to ESRD. We identified 12 such SNPs among black patients and six such SNPs among white patients. We were able to conduct follow-up analyses of three candidate SNPs in similar (replication) cohorts and eight candidate SNPs in phenotype-related (validation) cohorts. Among blacks without diabetes, rs653747 in LINC00923 replicated in the African American Study of Kidney Disease and Hypertension cohort (discovery P=5.42×10−7; replication P=0.039; combined P=7.42×10−9). This SNP also associated with ESRD (hazard ratio, 2.0 (95% confidence interval, 1.5 to 2.7); P=4.90×10−6). Similarly, rs931891 in LINC00923 associated with eGFR decline (P=1.44×10−4) in white patients without diabetes. In summary, SNPs in LINC00923, an RNA gene expressed in the kidney, significantly associated with CKD progression in individuals with nondiabetic CKD. However, the lack of equivalent cohorts hampered replication for most discovery loci. Further replication of our findings in comparable study populations is warranted.
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Date Issued: 2017-03-01
Identifier: fgcu_ir_000713
Format: Citation

Title: Genome-wide association studies in pediatric chronic kidney disease.
Creator: Gupta, Jayanta, Kanetsky, Peter, Wuttke, Matthias, Köttgen, Anna, Schaefer, Franz, Wong, Craig
Abstract / Description: The genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new perspectives regarding the genetic architecture of CKD progression by identifying new candidate genes and targets for intervention. As such, it has become an important arm of translational science providing a...
Show moreThe genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new perspectives regarding the genetic architecture of CKD progression by identifying new candidate genes and targets for intervention. As such, it has become an important arm of translational science providing a complementary line of investigation to identify novel therapeutics to treat CKD. In this review, we describe the method and the challenges of performing GWAS in the pediatric CKD population. We also provide an overview of successful GWAS for kidney disease, and we discuss the established pediatric CKD cohorts in North America and Europe that are poised to identify genetic risk variants associated with CKD progression.
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Date Issued: 2016-08-01
Identifier: fgcu_ir_000701
Format: Citation

Title: Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences.
Creator: Gupta, Jayanta, Butsch Kovacic, Melinda, Biagini Myers, Jocelyn M., Wang, Ning, Martin, Lisa J., Lindsey, Mark, Ericksen, Mark B., Hua, He, Patterson, Tia L., Baye, Tesfaye M.,...
Show moreGupta, Jayanta, Butsch Kovacic, Melinda, Biagini Myers, Jocelyn M., Wang, Ning, Martin, Lisa J., Lindsey, Mark, Ericksen, Mark B., Hua, He, Patterson, Tia L., Baye, Tesfaye M., Torgerson, Dara, Roth, Lindsey A., Sivaprasad, Umasundari, Gibson, Aaron M., Tsoras, Anna M., Hu, Donglei, Eng, Celeste, Chapela, Rocio, Rodriguez-Santana, Jose R.
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Abstract / Description: Asthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes.
Date Issued: 2011-08-30
Identifier: fgcu_ir_000724
Format: Document (PDF)

Title: Inflammation and Arterial Stiffness in Chronic Kidney Disease: Findings From the CRIC Study.
Creator: Gupta, Jayanta, Peyster, Eliot, Chen, Jing, Feldman, Harold I., Go, Alan S., Mitra, Nandita, Pan, Qiang, Porter, Anna, Rahman, Mahboob, Raj, Dominic, Reilly, Muredach, Wing,...
Show moreGupta, Jayanta, Peyster, Eliot, Chen, Jing, Feldman, Harold I., Go, Alan S., Mitra, Nandita, Pan, Qiang, Porter, Anna, Rahman, Mahboob, Raj, Dominic, Reilly, Muredach, Wing, Maria R., Yang, Wei
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Abstract / Description: Chronic kidney disease (CKD) and arterial stiffness are associated with increased cardiovascular morbidity and mortality. Inflammation is proposed to have a role in the development of arterial stiffness, and CKD is recognized as a proinflammatory state. Arterial stiffness is increased in CKD, and cross-sectional data has suggested a link between increased inflammatory markers in CKD and higher measures of arterial stiffness. However, no large scale investigations have examined the impact of...
Show moreChronic kidney disease (CKD) and arterial stiffness are associated with increased cardiovascular morbidity and mortality. Inflammation is proposed to have a role in the development of arterial stiffness, and CKD is recognized as a proinflammatory state. Arterial stiffness is increased in CKD, and cross-sectional data has suggested a link between increased inflammatory markers in CKD and higher measures of arterial stiffness. However, no large scale investigations have examined the impact of inflammation on the progression of arterial stiffness in CKD.
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Date Issued: 2017-04-01
Identifier: fgcu_ir_000711
Format: Citation

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