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The Master of Genomic Programs: HOTAIR in Cellular Development and Cancer Metastasis

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Date Issued:
2016
Summary:
Originally thought of as “junk RNA”, long non-coding RNA (lncRNA) has been shown over the last decade to play active regulatory roles in many vital cellular processes. The accepted primary mechanism of lncRNA regulatory activity is through chromatin remodeling and methylation of the genome, while there are also recent data to suggest additional mechanisms, such as altered RNA processing and enhancer activity. Aberrant expression of lncRNA has been linked with various disease processes, including cancer. One of the most well studied lncRNA, Hox Transcript Antisense Intergenic RNA (HOTAIR), is one such lncRNA whose enhanced expression has been associated with carcinomas of the breast. In addition to reviewing the extensive research focused on HOTAIR expression and regulation of breast cancer through canonical pathways, we will examine new studies that suggest the ability of HOTAIR to regulate microRNA (another type of non-coding RNA) through direct binding inhibition, and how dysregulation of HOTAIR expression is relevant to breast cancer.
Title: The Master of Genomic Programs: HOTAIR in Cellular Development and Cancer Metastasis.
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Name(s): Hammer, Talia, author
Lohbauer, Sara, author
Aquila: The FGCU Student Research Journal Vol. III, Issue 1
Type of Resource: text
Genre: Article.
Issuance: single unit
Date Issued: 2016
Publisher: Florida Gulf Coast University
Place of Publication: Fort Myers, FL
Extent: 7 pgs.
Language(s): English
Summary: Originally thought of as “junk RNA”, long non-coding RNA (lncRNA) has been shown over the last decade to play active regulatory roles in many vital cellular processes. The accepted primary mechanism of lncRNA regulatory activity is through chromatin remodeling and methylation of the genome, while there are also recent data to suggest additional mechanisms, such as altered RNA processing and enhancer activity. Aberrant expression of lncRNA has been linked with various disease processes, including cancer. One of the most well studied lncRNA, Hox Transcript Antisense Intergenic RNA (HOTAIR), is one such lncRNA whose enhanced expression has been associated with carcinomas of the breast. In addition to reviewing the extensive research focused on HOTAIR expression and regulation of breast cancer through canonical pathways, we will examine new studies that suggest the ability of HOTAIR to regulate microRNA (another type of non-coding RNA) through direct binding inhibition, and how dysregulation of HOTAIR expression is relevant to breast cancer.
Identifier: fgcu_aquila_0032 (IID)
Subject(s): HOTAIR
long non-coding RNA
Cancer Metastasis
MicroRNA.
Non-coding RNA.
Persistent Link to This Record: http://purl.flvc.org/fgcu/fd/fgcu_aquila_0032
Host Institution: FGCU